BIOSCALE − Establishment of biological scale-up parameters for the scaling of biotechnological processes

Sustainable and innovative biotechnological processes provide key approaches for solving major societal challenges such as climate change, the energy crisis and increasing supply demands. In the course of the transformation from a petroleum-based to a bio-based economy, bioprocess engineering represents a key technology. It enables biotechnological processes to be transferred from laboratory scale to industrial scale (scaling up).

The goal of Dr. Nadja Henke's project is the development and scaling of bioprocesses through an innovative, biotechnological, data-driven concept. The focus is on the development of novel scaling strategies based on biological insights. The complex interaction between the bioreactor environment and the cellular response is captured by systematically collecting transcriptome data from bioprocesses under variation of scale-up criteria.