Genes vs. Environment interaction: Defining a link between epigenetic stability and genomic integrity following BAP1 inactivation

The research project focuses on the BAP1 gene. Familiar mutations of this gene create predisposition to the development of some types of cancer such as mesothelioma and ocular melanomas. The goal of the grant is to find evidence that the loss of BAP1 causes a loss of epigenetic integrity that might underlie its role in tumour suppression and genomic stability. The grant is intended to establish a new line of research at Professor Amelio's department. A new hypothesis in the context of BAP1 research will be verified.